Dr. Josef Steiner
The Dr. Josef Steiner Cancer Research Foundation

1991 6. Dr. Josef Steiner Cancer Research Prize

Dr. Victor Ling

Dr. Victor Ling

Professor, Department of

Medical Biophysics

University of Toronto

Head, Division of Molecular

and Structural Biology

The Ontario Cancer Institute

Toronto, Canada M4X 1K9

Deciphering the mechanisms why cancer cells become resistant to chemotherapy is the main theme of Victor Ling's work. He discovered and analyzed a membrane protein (P-Glycoprotein) that pumps a variety of anticancer drugs out of malignant cells before these drugs have a chance to act. Based on V. Ling's studies, clinical trials are underway which use immune suppressive drugs that clog the membrane pumps allowing previously resistant cells to become sensitive again.